Articles of the FEBS Journal thematic MiniReview Series:

1. “Proteoglycans in health and disease: emerging concepts and future directions (coordinators: Renato Iozzo and Nikos Karamanos)”, and
2. “Metalloproteinases in health and disease: challenges and the future prospects (coordinators: Hideaki Nagase and Nikos Karamanos)”

have been identified as the top most-cited website of the FEBS Journal papers 2013 (two years from publication period October 2010 – March 2011)

Moreover the articles:

1. Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting, has the first position in the most cited of the past 10 years as indicated in January 2017
   
   most cited 10-years the febs journal
   and
2. Glycosaminoglycans: key players in cancer cell biology and treatment, received the third position in the most cited of the past 5-years as indicated in January 2017
   
   most cited 5-years the febs journal

For more info:http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1742-4658/homepage/MostCited.html

FEBS Journal Special Issue

Proteoglycans: signaling, targeting and therapeutics

Volume 280, Issue 10, May 2013, Pages i–iii, 2119–2534

Nikos K. Karamanos and Robert J. Linhardt

http://onlinelibrary.wiley.com/doi/10.1111/febs.2013.280.issue-10/issuetoc

This special issue of FEBS Journal contains 31 review and primary research articles reflecting the advancements covered at the 2012 Proteoglycans Gordon Research Conference and novel aspects from experts in the field. It is mainly focused on current status of the extracellular and cell surface proteoglycans’ regulatory roles in cell signaling, molecular targeting, engineering attempts and potential therapeutic approaches.

Extracellular Matrix: Pathobiology and Signaling

Ed. by Nikos Karamanos,

ISBN: 978-3-11-025877-6

http://www.degruyter.com/view/product/174386

• Comprehensive treatment of the extracellular matrix with special focus on matrix pathobiology and cell molecular biology
• Role of the extracellular matrix in health and disease with outlook for biotechnological and pharmacological applications
• High quality color illustrations

Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting.
It will provide an introduction to the extracellular matrix and detailed sections and chapters on:

• Importance of extracellular matrix in health and disease
• Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin)
• Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system)
• Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer,  inflammation and metabolic control)
• Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases)
• Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR).
• Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics).

"The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications."

Dick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden